The -6.1-kilobase chicken lysozyme enhancer is a multifactorial complex containing several cell-type-specific elements.

@article{Grewal1992TheC,
  title={The -6.1-kilobase chicken lysozyme enhancer is a multifactorial complex containing several cell-type-specific elements.},
  author={T Grewal and M. Theisen and Uwe Borgmeyer and T. Grussenmeyer and Ralph A.W Rupp and Aribert Stief and Feng Qian and Andreas Hecht and A. E. Sippel},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 5},
  pages={2339-50}
}
In the chromatin domain of the chicken lysozyme gene of myeloid and oviduct cells, which both have the potential to activate the gene, a developmentally stable DNase I-hypersensitive site is formed around 6.1 kb upstream of the gene. This implies that this DNA region, which has previously been demonstrated to function as a transcriptional enhancer element in myeloid cells, is intimately involved in the cell-type-specific activation of the lysozyme gene locus. Deletion analysis identifies a 157… CONTINUE READING
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