The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia

  title={The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia},
  author={Chao A. Hsiung and Qing Lan and Yun Chul Hong and C. -J. Chen and Howard Dean Hosgood and I-shou Chang and Nilanjan Chatterjee and Paul Brennan and Chen Wu and Wei Zheng and G. -t. Chang and Tangchun Wu and Jae Yong Park and Chin-Fu Hsiao and Yeul Hong Kim and Hongbing Shen and Adeline L H Seow and Meredith Yeager and Y B Tsai and Young Tae Kim and Wong-Ho Chow and Huan Guo and Wen-Chang Wang and Sook Whan Sung and Zhibin Hu and Kuan-Yu Chen and Jeonghyun Kim and Yin Chen and Liming Huang and Kyoung-Mu Lee and Y L Lo and Yu-tang Gao and Jin Hee Kim and Li Liu and M W Huang and Tae Hoon Jung and Guangfu Jin and Neil Caporaso and Dianke Yu and Chang Ho Kim and W Su and Xiao-ou Shu and Ping Xu and In-San Kim and Yuh-Min Chen and Hongxia Ma and Min Shen and Seung Ick Cha and Wen Tan and Chin-Hao Chang and Jae Sook Sung and MingFeng Zhang and Tsung-Ying Yang and Kyong Hwa Park and Jeff Yuenger and Chih-Liang Wang and Jeong-Seon Ryu and Yongbing Xiang and Qifei Deng and Amy Hutchinson and Jun Suk Kim and Qiuyin Cai and Maria Teresa Landi and Chong-Jen Yu and Ju-Yeon Park and Margaret Tucker and J B Hung and Chien Lin and R I Perng and Paolo Boffetta and Chih-Yi Chen and Kun-Chieh Chen and S Yang and Chi-Yuan Hu and Chung-Kai Chang and Joseph F. Jr. Fraumeni and Stephen J. Chanock and Pan-Chyr Yang and Nathaniel Rothman and Dongxin Lin},
  booktitle={PLoS genetics},
Genome-wide association studies of lung cancer reported in populations of European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that have achieved genome-wide significance with p-values of 10(-7) or lower. These studies have been performed primarily in cigarette smokers, raising the possibility that the observed associations could be related to tobacco use, lung carcinogenesis, or both. Since most women in Asia do not smoke, we conducted a genome-wide… CONTINUE READING
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