The 5S gene internal control region is composed of three distinct sequence elements, organized as two functional domains with variable spacing.

@article{Pieler1987The5G,
  title={The 5S gene internal control region is composed of three distinct sequence elements, organized as two functional domains with variable spacing.},
  author={Tomas Pieler and J{\"o}rg Hamm and Robert G Roeder},
  journal={Cell},
  year={1987},
  volume={48 1},
  pages={91-100}
}
Systematic oligonucleotide-directed mutagenesis within the internal control region of the Xenopus laevis somatic 5S RNA gene identifies three distinct sequence elements that regulate transcription activity: box A, containing the common, conserved class III promoter domain, and two 5S-gene-specific segments, termed intermediate element and box C. Analysis of the individual steps in the formation of the stable initiation complex reveals that the two 5S-gene-specific elements are the main… CONTINUE READING
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