The 5A apolipoprotein A-I mimetic peptide displays antiinflammatory and antioxidant properties in vivo and in vitro.

@article{Tabet2010The5A,
  title={The 5A apolipoprotein A-I mimetic peptide displays antiinflammatory and antioxidant properties in vivo and in vitro.},
  author={Fatiha Tabet and Alan T Remaley and Aude I S{\'e}galiny and Jonathan R M Millet and Ling G Yan and Shirley Nakhla and Philip J. Barter and Kerry-Anne Rye and Gilles Lambert},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2010},
  volume={30 2},
  pages={246-52}
}
OBJECTIVE The apolipoprotein (apo)A-I mimetic peptide 5A is highly specific for ATP-binding cassette transporter (ABC)A1-mediated cholesterol efflux. We investigated whether the 5A peptide shares other beneficial features of apoA-I, such as protection against inflammation and oxidation. Methods- New Zealand white rabbits received an infusion of apoA-I, reconstituted high-density lipoprotein (HDL) containing apoA-I ([A-I]rHDL), or the 5A peptide complexed with phospholipids (1-palmitoyl-2… CONTINUE READING

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