The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties.

@article{Barber1994The5I,
  title={The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties.},
  author={Glen N Barber and Stephen E. Thompson and Taehoon G. Lee and Tim Strom and Rosemary Jagus and Andr{\'e} Darveau and Michael G. Katze},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 10},
  pages={4278-82}
}
The interferon-induced RNA-dependent protein kinase (PKR) is considered to play an important role in the cellular defense against viral infection and, in addition, has been suggested to be a tumor suppressor gene because of its growth-suppressive properties. Activation of PKR by double-stranded RNAs leads to the phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF-2 alpha) and a resultant block to protein synthesis initiation. To avoid the consequences of kinase… CONTINUE READING

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