The 5-hydroxytryptamine-releasing properties of two epimer quinoline derivatives

  title={The 5-hydroxytryptamine-releasing properties of two epimer quinoline derivatives},
  author={G. Le Fur and F. Imbault and N. Mitrani and F Marquis and Christian Renault and Marie Christine Dubroeucq and Claude Gueremy and Andr{\'e} Uzan},
6 Citations
Differential Interaction of Phencyclidine‐Like Drugs with the Dopamine Uptake Complex In Vivo
The results imply that the pharmacological effects of PCP are due to its simultaneous interaction with the dopamine uptake complex and the PCP receptor, and TCP and MK‐801, which have the same behavioral properties as PCP, exert their action only through the interaction withThe PCP receptors.
Pharmacokinetics and bioavailability of viqualine a new antidepressant
SummaryA high performance liquid chromatographic assay was developed for plasma and urine levels measurement of viqualine. The assay was used to study the disposition of 25 mg intravenous and oral
Quantitative Autoradiography of [3H]Indalpine Binding Sites in the Rat Brain: I. Pharmacological Characterization
Electrolytic lesions of the dorsal raphe or medial forebrain bundle, which cause a degeneration of 5‐HT cell bodies and fibers, respectively, resulted in a 30–40% reduction in the binding of [3H]indalpine.
The radiosynthesis of nca [O‐methyl‐11C]viqualine, through an N‐trityl‐protected intermediate, as a potential pet radioligand for 5HT re‐uptake sites
Viqualine, {4-[3-[3(R)-ethenyl-4(R)-piperidinyl]propyl]-6-methoxyquinoline}, has been labelled in the O-methyl position with no-carrier-added (nca) carbon-11 (t1/2 = 20.4 min; β+ = 99.8%) to provide
Isomérisation cis‐trans en Série Alkyl‐4‐vinyl‐3‐pipéridine par Sigmatropie [3.3]. Synthèse des Epivinyl Isomères des Alcaloïdes du Quinquina
cis, trans Isomerization of 4-Alkyl-3-vinylpiperidines by [3.3] Sigmatropic Rearrangement. Synthesis of Epivinyl Isomers of Cinchona Alkaloids Isomerization of 4-alkyl-3-vinylpiperidines


Monoamine oxidase inhibitory properties of 5‐hydroxymethyl‐3‐m‐tolyloxazolidin‐2‐one (toloxatone)
This paper reports on the monoamine oxidase inhibiting properties in virro and in vivo, of a new oxazolidin-2-one derivative with antidepressant activity in animals and potential clinical efficacy in man.
The importance of neuronal uptake of amines for amphetamine-induced release of 3H-norepinephrine from isolated brain tissue.
The results indicate that amphetamine is transported by the neuronal uptake system and that cocaine and desipramine inhibit the release of 3 H-norepinephrine at low concentrations of amphetamine by inhibiting the transport of Amphetamine into the neuron.
Platelet 5-HT uptake and release stopped rapidly by formaldehyde
The treatment of platelets with formaldehyde is described, which seems to provide a tool for precise studies of the kinetics of uptake and release of 5-hydroxytryptamine.