The 5-hydroxytryptamine 2A receptor agonists DOI and 25CN-NBOH decrease marble burying and reverse 8-OH-DPAT-induced deficit in spontaneous alternation

@article{Odland2021The52,
  title={The 5-hydroxytryptamine 2A receptor agonists DOI and 25CN-NBOH decrease marble burying and reverse 8-OH-DPAT-induced deficit in spontaneous alternation},
  author={Anna U Odland and Lea Jessen and Jesper L. Kristensen and Ciar{\'a}n Martin Fitzpatrick and Jesper T. Andreasen},
  journal={Neuropharmacology},
  year={2021},
  volume={183}
}
The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice
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The results suggest that 25CN-NBOH does not affect reversal learning in the schedule used in this study, and no effects were observed on acquisition of the new stimulus-reward contingency, learning errors, or perseverative responses during reversal.
Effects of a psychedelic 5-HT2A receptor agonist on anxiety-related behavior and fear processing in mice
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It is demonstrated that activation of 5-HT2A receptors in the amygdala suppresses fear expression but provide no evidence for an effect on retention of fear extinction.
The Chronic Treatment With 5-HT2A Receptor Agonists Affects the Behavior and the BDNF System in Mice.
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It is shown for the first time that the chronic activation of the 5-HT2A receptor with agonists has affected the BDNF system almost on all levels-transcription, proBDNF production, TrkB and p75NTR receptors' level.
Sequential reversal learning: a new touchscreen schedule for assessing cognitive flexibility in mice.
TLDR
Developing a free-choice reversal learning test, where images are presented sequentially and animals are free to move, to enable investigation of the cognitive sub-processes that occur during reversal, found that exploitation of the previously rewarded image was independent of exploration and acquisition of the new reward contingency and could be differentially modulated by fluoxetine, supporting recent theories that these processes are not mutually exclusive.
SEROTONIN 1B/1A RECEPTOR MODULATION ON BEHAVIORAL FLEXIBILITY IN C57BL/6J MICE
TLDR
This chapter discusses the development of spatial Probabilistic Reversal Learning in the context of an OBSESSIVE-COMPULSIVE DISORDER.

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