The 5-Lipoxygenase as modulator of Alzheimer's γ-secretase and therapeutic target.

@article{Chu2016The5A,
  title={The 5-Lipoxygenase as modulator of Alzheimer's γ-secretase and therapeutic target.},
  author={Jin Woo Chu and Domenico Pratic{\`o}},
  journal={Brain research bulletin},
  year={2016},
  volume={126 Pt 2},
  pages={207-212}
}
Alzheimer's disease (AD) is an age-related, neurodegenerative disorder characterized by cognitive impairment with memory loss, extracellular amyloid beta (Aβ) peptides aggregation, and intracellular hyper-phosphorylated tau neurofibrillary tangles (NFT) accumulation. Although the 5-lipoxygenase (5LO) protein enzyme is well known as an important modulators of oxidation and inflammation, recent work has highlighted the new hypothesis that this pathway may play a direct role in AD pathogenesis. In… CONTINUE READING
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