The 5-HT3B subunit is a major determinant of serotonin-receptor function

@article{Davies1999The5S,
  title={The 5-HT3B subunit is a major determinant of serotonin-receptor function},
  author={Paul A. Davies and Marco Pistis and Michael C. Hanna and J Andrew Peters and J J Lambert and Tim G Hales and Ewen F. Kirkness},
  journal={Nature},
  year={1999},
  volume={397},
  pages={359-363}
}
The neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) mediates rapid excitatory responses through ligand-gated channels (5-HT3 receptors). Recombinant expression of the only identified receptor subunit (5-HT3A) yields functional 5-HT3 receptors. However, the conductance of these homomeric receptors (sub-picosiemens) is too small to be resolved directly, and contrasts with a robust channel conductance displayed by neuronal 5-HT3 receptors (9–17 pS). Neuronal 5-HT3 receptors also display a… CONTINUE READING
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