The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors.

@article{Zeitz2002The5S,
  title={The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors.},
  author={Karla P Zeitz and Nicolas Guy and Annika B. Malmberg and Sahera Dirajlal and William J Martin and Linda Sun and D. W. Bonhaus and Cheryl L Stucky and David Julius and Allan I. Basbaum},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 3},
  pages={
          1010-9
        }
}
Serotonin is a major component of the inflammatory chemical milieu and contributes to the pain of tissue injury via an action on multiple receptor subtypes. Here we studied mice after genetic or pharmacological disruption of the 5-HT(3) receptor, an excitatory serotonin-gated ion channel. We demonstrate that tissue injury-induced persistent, but not acute, nociception is significantly reduced after functional elimination of this receptor subtype. Specifically, in the setting of tissue injury… CONTINUE READING
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