The 5-HT3 receptor ligand, [3H]BRL 43694, binds to presynaptic sites in the nucleus tractus solitarius of the rat.

@article{Pratt1989The5R,
  title={The 5-HT3 receptor ligand, [3H]BRL 43694, binds to presynaptic sites in the nucleus tractus solitarius of the rat.},
  author={Gerard D Pratt and Norman G. Bowery},
  journal={Neuropharmacology},
  year={1989},
  volume={28 12},
  pages={1367-76}
}
This study has employed receptor autoradiography to localise the distribution of binding sites for the 5-HT3 receptor ligand [3H]BRL 43694 in sections of the brain of the rat (using a concentration of 10 nM [3H]BRL 43694 with 100 microM GR38032F to define non-specific binding). The highest density of binding sites for [3H]BRL 43694 was observed in the nucleus tractus solitarius and amounted to 652 fmol/mg tissue. The binding of [3H]BRL 43694 was also examined in sections prepared 10 days after… CONTINUE READING