The 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide facilitates noradrenaline release by blockade of α2-adrenoceptors in the mouse brain cortex

@article{Schlicker1994The5R,
  title={The 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide facilitates noradrenaline release by blockade of α2-adrenoceptors in the mouse brain cortex},
  author={Eberhard Schlicker and Markus Kathmann and Hans Juha Exner and M. Detzner and Manfred G{\"o}thert},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1994},
  volume={349},
  pages={20-24}
}
We analyzed the facilitatory effect of the 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide (mCPBG) on the electrically evoked noradrenaline release in superfused mouse brain tissue. In addition, we determined the affinities of mCPBG and two other 5-HT receptor ligands, namely, 2-methyl-5-hydroxytryptamine (2-methyl-5-HT; also a 5-HT3 receptor agonist) and 5-carboxamidotryptamine (5-CT; a 5-HT1 receptor agonist) for α2 binding sites. The latter two 5-HT receptor agonists were included… CONTINUE READING
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