The 5-HT3 receptor agonist 2-methyl-5-HT reduces postsynaptic potentials in rat CA1 pyramidal neurons of the hippocampus in vitro.


The effects of the serotonin (5-HT)3 receptor agonist, 2-methyl-5-hydroxytryptamine (2-methyl-5-HT), were studied in CA1 pyramidal cells of the rat hippocampus in vitro using the whole cell gigaseal technique. 2-Methyl-5-HT (10 and 50 microM) did not change significantly the electrophysiologic properties of the cells but reversibly reduced excitatory and… (More)


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