The 5-HT2C receptor and antipsychoticinduced weight gain - mechanisms and genetics.

@article{Reynolds2006The5R,
  title={The 5-HT2C receptor and antipsychoticinduced weight gain - mechanisms and genetics.},
  author={Gavin Paul Reynolds and Matthew J Hill and Shona L. Kirk},
  journal={Journal of psychopharmacology},
  year={2006},
  volume={20 4 Suppl},
  pages={15-8}
}
The mechanisms underlying weight gain resulting from antipsychotic drugs are not fully understood, although antagonism of the 5-HT2C receptor is likely to contribute. Animal studies indicate that the drugs most likely to cause weight gain, clozapine and olanzapine, have direct effects on the NPY-containing neurons of the hypothalamus; these neurons mediate the effects of the circulating anorexigenic hormone leptin on the control of food intake. The substantial differences between individuals in… CONTINUE READING