The 5-HT2 antagonist ritanserin decreases sleep in cats.


Sleep and wakefulness were recorded in cats after oral administration of the 5-HT2 antagonist ritanserin at doses of 0.5 and 1.0 mg/kg (n = 6), and after 2.5 mg/kg (n = 3). A subgroup (n = 4) of the animals also received the selective 5-HT uptake inhibitor zimeldine and a combination of ritanserin and zimeldine. The drugs were administered shortly after… (More)


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