The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels.

Abstract

BACKGROUND AND PURPOSE Ketanserin, a selective 5-HT receptor antagonist, prolongs the QT interval of ECG in patients. The purpose of the present study was to determine whether ketanserin would block human cardiac ether-à-go-go-related gene (hERG) potassium channels. EXPERIMENTAL APPROACH Whole-cell patch voltage-clamp technique was used to record membrane… (More)
DOI: 10.1038/bjp.2008.261

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Cite this paper

@article{Tang2008The5A, title={The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-{\`a}-go-go-related gene (hERG) potassium channels.}, author={Qi Tang and Zhouqi Li and Wenjia Li and J. Guo and H-Y Sun and Xin-Hua Zhang and C-P Lau and H-F. Tse and S. Zhang and G-R Li}, journal={British journal of pharmacology}, year={2008}, volume={155 3}, pages={365-73} }