The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence

@article{Halford1996The5R,
  title={The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence},
  author={Jason C G Halford and John E Blundell},
  journal={Physiology \& Behavior},
  year={1996},
  volume={60},
  pages={933-939}
}

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CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety

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Evidence suggests that serotonergic drugs can continue to play a useful role in the treatment of obesity and whether serotonin-based interventions are appropriate for the binge eating subpopulation of obese people and for those individuals displaying binge eating disorder.

Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat

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The effects of serotonergic drugs on rodent and human appetite expression will be examined along with the effects of some of these drugs on body weight.

Role of 5-HT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat

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  • 2002

Role of 5-hydroxytryptamine 1B (5-HT1B) receptors in the regulation of ethanol intake in rodents

  • Y. Sari
  • Medicine, Biology
    Journal of psychopharmacology
  • 2013
TLDR
This review on the role of 5-HT1B receptors in neurotransmitter release and consequent alcohol intake provides important information about the potential therapeutic role of 4-HT2A receptors for the treatment of alcohol dependence.

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Evidence indicates that tesofensine strengthens satiety, but behavioural specificity and psychological side effects remain an issue, and the serotonergic system remains a viable target for anti-obesity treatment.
...

References

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Effects of tryptophan and of 5-hydroxytryptamine receptor subtype agonists on feeding.

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TLDR
5-HT1A agonists (8-OH-DPAT, buspirone, gepirone etc.) stimulate intake in freely feeding rats, probably by activating autoreceptors on the cell bodies of 5- HT neurons so that 5-HT release at terminals is decreased and feeding in previously food deprived rats is decreased.

5-HT1B agonists induce anorexia at a postsynaptic site.

Serotonin and Appetite

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  • Biology
    Annals of the New York Academy of Sciences
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TLDR
5-HT1A agonists (8-OHDPAT, buspirone, gepirone, etc.) stimulate intake in freely feeding rats, probably by activating autoreceptors on the cell bodies of 5- HT neurons so that 5-HT release at terminals is decreased and feeding in previously food-deprived rats is decreased.

Biochemical and behavioral studies of the 5‐HT1B receptor agonist, CP‐94,253

CP‐94,253, 3‐(1,2,5,6‐tetrahydro‐4‐pyridyl)‐5‐propoxypyrrolo[3,2‐b]pyridine, a new serotonergic ligand, was found to exhibit significantly greater binding affinity at 5‐HT1B receptors than at 5‐HT1A

Cholecystokinin elicits the complete behavioral sequence of satiety in rats.

TLDR
The observation that cholecystokinin not only stops feeding but elicits the complete sequence of satiety supports the hypothesis that endogenous cholecentokinin is a satiety signal for the rat.

MicroComputers, Psychology and Medicine

TLDR
Written by authorities who use micros in their everyday activities, it provides superlative guidance that demonstrates the various uses which micros have to offer and how to get the most out of them.