The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence

@article{Halford1996The5R,
  title={The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence},
  author={Jason C G Halford and John E Blundell},
  journal={Physiology \& Behavior},
  year={1996},
  volume={60},
  pages={933-939}
}

5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253

Findings imply that 5-HT1B receptors regulate discrete elements of satiety and the potential role of 5- HT1B agonists for the treatment of obesity is discussed.

Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse

5-HT2C-R and 5-HT1B-R activation are each sufficient to induce a hypophagic response, however, concurrent 5- HT2c-R inactivation can potentiate the hypophotic response to 5-ht1b-Ractivation, consistent with an inhibitory role for the 5-hydroxytryptamine-based response in behaviour mediated by the activation of other 4-HT receptors.

CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety

The results imply that CP-94,253 probes a role for central 5- HT1B receptors in the regulation of meal size and duration, but that recruitment of other 5-HT receptor subtypes may be needed for the full expression of satiety.

Serotonin and Appetite Regulation

Evidence suggests that serotonergic drugs can continue to play a useful role in the treatment of obesity and whether serotonin-based interventions are appropriate for the binge eating subpopulation of obese people and for those individuals displaying binge eating disorder.

Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat

The hypothesis that activation of 5-HT2C receptors is a critical aspect of the hypophagic action of d-fenfluramine is supported and may prove to be a useful target in the development of clinically effective drugs for the treatment of obesity.

The Role of Serotonin in Eating Behavior: Focus on 5-HT2C Receptors

The effects of serotonergic drugs on rodent and human appetite expression will be examined along with the effects of some of these drugs on body weight.

Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats

The results implicate parabrachial 5-HT1B receptors in mediating serotonergic enhancement of satiation and implicate the PBN of the pons in this agonist-induced reduction in food consumption by rats.

Role of 5-HT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat

  • R. SchreiberJ. Vry
  • Biology, Medicine
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2002
...

References

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Effects of tryptophan and of 5-hydroxytryptamine receptor subtype agonists on feeding.

  • G. Curzon
  • Biology
    Advances in experimental medicine and biology
  • 1991
5-HT1A agonists (8-OH-DPAT, buspirone, gepirone etc.) stimulate intake in freely feeding rats, probably by activating autoreceptors on the cell bodies of 5- HT neurons so that 5-HT release at terminals is decreased and feeding in previously food deprived rats is decreased.

5-HT1B agonists induce anorexia at a postsynaptic site.

Serotonin and Appetite

  • G. Curzon
  • Biology
    Annals of the New York Academy of Sciences
  • 1990
5-HT1A agonists (8-OHDPAT, buspirone, gepirone, etc.) stimulate intake in freely feeding rats, probably by activating autoreceptors on the cell bodies of 5- HT neurons so that 5-HT release at terminals is decreased and feeding in previously food-deprived rats is decreased.

Biochemical and behavioral studies of the 5‐HT1B receptor agonist, CP‐94,253

CP‐94,253, 3‐(1,2,5,6‐tetrahydro‐4‐pyridyl)‐5‐propoxypyrrolo[3,2‐b]pyridine, a new serotonergic ligand, was found to exhibit significantly greater binding affinity at 5‐HT1B receptors than at 5‐HT1A

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