The 5-HT1A receptor and 5-HT transporter in temporal lobe epilepsy.

OBJECTIVE To study 5-HT transport and 5-HT1A receptors in temporal lobe epilepsy (TLE) and depression. METHODS Thirteen patients had PET with [(11)C]DASB for 5-HTT and [(18)F]FCWAY for 5-HT1A receptor binding, MRI, and psychiatric assessment. Sixteen healthy volunteers had [(11)C]DASB, 19 had [(18)F]FCWAY, and 6 had both PET studies. We used a reference… CONTINUE READING