The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment.

@article{Svejda2010The5R,
  title={The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment.},
  author={Bernhard Svejda and M. N. Kidd and F Giovinazzo and Karim M Eltawil and Bjorn I. Gustafsson and Roswitha Pfragner and Irvin Mark Modlin},
  journal={Cancer},
  year={2010},
  volume={116 12},
  pages={2902-12}
}
BACKGROUND Fibrosis is a cardinal feature of small intestinal neuroendocrine tumors (SI-NETs) both in local peritumoral tissue and systemic sites (cardiac). 5-HT, a commonly secreted NET amine, is a known inducer of fibrosis, although the mechanistic basis for it and growth factors regulating fibrosis and proliferation in the tumor microenvironment are unclear. We hypothesized that targeting 5-HT(2B) receptors on tumor cells would inhibit SI-NET 5-HT release and, thereby, fibroblast activation… CONTINUE READING