The 5'-AG5 CC-3' Fragment from the Human CPEB3 Ribozyme Forms an Ultrastable Parallel RNA G-Quadruplex.

Abstract

An unusually thermostable G-quadruplex is formed by a sequence fragment of a naturally occurring ribozyme, the human CPEB3 ribozyme. Strong evidence is provided for the formation of a uniquely stable intermolecular G-quadruplex structure consisting of five tetrad layers, by using CD spectroscopy, UV melting curves, 2D NMR spectroscopy, and gel shift analysis. The cationic porphyrin TMPyP4 destabilizes the complex.

DOI: 10.1002/cbic.201700028

Cite this paper

@article{Kulikov2017The5C, title={The 5'-AG5 CC-3' Fragment from the Human CPEB3 Ribozyme Forms an Ultrastable Parallel RNA G-Quadruplex.}, author={Katharina Kulikov and Senada No{\vz}inovi{\'c} and Stephanie Kath-Schorr}, journal={Chembiochem : a European journal of chemical biology}, year={2017}, volume={18 11}, pages={969-973} }