The 5 9 and 3 9 domains of yeast U 6 snRNA : Lsm proteins facilitate binding of Prp 24 protein to the U 6 telestem region

@inproceedings{Ryan2002The59,
  title={The 5 9 and 3 9 domains of yeast U 6 snRNA : Lsm proteins facilitate binding of Prp 24 protein to the U 6 telestem region},
  author={Daniel E. Ryan and Scott W. Stevens and John Abelson},
  year={2002}
}
The 59 and 39 domains of yeast U6 snRNA contain sequences that are thought to be important for binding to Prp24 and Lsm proteins. By extensive mutational analysis of yeast U6 snRNA, we confirmed that the 3 9 terminal uridine tract of U6 snRNA is important for U6 binding to Lsm proteins in yeast. Binding of Prp24 protein to U6 RNA is dependent on or is strongly enhanced by U6 binding of Lsm proteins. This supports a model for U6 snRNP assembly in which U6 RNA binds to the Lsm2–8 core prior to… CONTINUE READING
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+ Multiple functional interactions between components of the Lsm 2Lsm 8 complex , U 6 snRNA , and the yeast La protein +

  • PL Raghunathan, C Guthrie
  • Genetics
  • 2001

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