The 5' ends of Hantaan virus (Bunyaviridae) RNAs suggest a prime-and-realign mechanism for the initiation of RNA synthesis.

@article{Garcin1995The5E,
  title={The 5' ends of Hantaan virus (Bunyaviridae) RNAs suggest a prime-and-realign mechanism for the initiation of RNA synthesis.},
  author={Dominique Garcin and Markus Lezzi and M Dobbs and Richard M. Elliott and Connie S. Schmaljohn and C. Yong Kang and Daniel Kolakofsky},
  journal={Journal of virology},
  year={1995},
  volume={69 9},
  pages={
          5754-62
        }
}
We examined the 5' ends of Hantaan virus (HTN) genomes and mRNAs to gain insight into the manner in which these chains were initiated. Like those of all members of the family Bunyaviridae described so far, the HTN mRNAs contained 5' terminal extensions that were heterogeneous in both length and sequence, presumably because HTN also "cap snatches" host mRNAs to initiate the viral mRNAs. Unexpectedly, however, almost all of the mRNAs contained a G residue at position -1, and a large fraction also… CONTINUE READING

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