The 5′-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding

@inproceedings{Bisio2015The5R,
  title={The 5′-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding},
  author={Alessandra Bisio and Elisa Latorre and Virginia Andreotti and Brigitte Bressac-de Paillerets and Mark Harland and Giovanna Bianchi Scarr{\`a} and Paola Ghiorzo and Robert C. Spitale and Alessandro Provenzani and Alberto Inga},
  booktitle={Oncotarget},
  year={2015}
}
CDKN2A/p16INK4a is an essential tumor suppressor gene that controls cell cycle progression and replicative senescence. It is also the main melanoma susceptibility gene. Here we report that p16INK4a 5'UTR mRNA acts as a cellular Internal Ribosome Entry Site (IRES). The potential for p16INK4a 5'UTR to drive cap-independent translation was evaluated by dual-luciferase assays using bicistronic and monocistronic vectors. Results of reporters' relative activities coupled to control analyses for… CONTINUE READING
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Functional analysis of CDKN2A/p16INK4a 5′-UTR variants predisposing to melanoma

  • A Bisio
  • Hum Mol Genet
  • 2010
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