The 5,7-DHT-induced anticonflict effect is dependent on intact adrenocortical function.

@article{Sderpalm1992The5A,
  title={The 5,7-DHT-induced anticonflict effect is dependent on intact adrenocortical function.},
  author={Bo S{\"o}derpalm and J{\"o}rgen A. Engel},
  journal={Life sciences},
  year={1992},
  volume={51 5},
  pages={
          315-26
        }
}
We have recently reported that the anxiolytic-like effect observed in rats severely depleted of brain serotonin (5-HT) by means of 5,7-DHT is indirect and probably involves the GABA(A)/benzodiazepine chloride ionophore receptor complex (GABAA/BDZ-RC). One tentative explanation for this effect considered the involvement of corticosteroids. In the present series of experiments we have therefore investigated the effect of adrenalectomy (ADX) on the 5,7-DHT-induced anxiolytic-like effect displayed… CONTINUE READING