The 5' untranslated region of alfalfa mosaic virus RNA 1 is involved in negative-strand RNA synthesis.

@article{Vlot2003The5U,
  title={The 5' untranslated region of alfalfa mosaic virus RNA 1 is involved in negative-strand RNA synthesis.},
  author={A Corina Vlot and John F. Bol},
  journal={Journal of virology},
  year={2003},
  volume={77 20},
  pages={11284-9}
}
The three genomic RNAs of alfalfa mosaic virus each contain a unique 5' untranslated region (5' UTR). Replacement of the 5' UTR of RNA 1 by that of RNA 2 or 3 yielded infectious replicons. The sequence of a putative 5' stem-loop structure in RNA 1 was found to be required for negative-strand RNA synthesis. A similar putative 5' stem-loop structure is present in RNA 2 but not in RNA 3. 

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Role of the 5 leader sequence of alfalfa mosaic virus RNA 3 in replication and translation of the viral RNA

  • E.A.G. Van der Vossen, L. Neeleman, J. F. Bol
  • Nucleic Acids Res
  • 1993
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