The 5'-flanking region of the RP58 coding sequence shows prominent promoter activity in multipolar cells in the subventricular zone during corticogenesis.

@article{OhtakaMaruyama2012The5R,
  title={The 5'-flanking region of the RP58 coding sequence shows prominent promoter activity in multipolar cells in the subventricular zone during corticogenesis.},
  author={Chiaki Ohtaka-Maruyama and Shinobu Hirai and Akiko Miwa and Akiyo Takahashi and Haruo Okado},
  journal={Neuroscience},
  year={2012},
  volume={201},
  pages={67-84}
}
Pyramidal neurons of the neocortex are produced from progenitor cells located in the neocortical ventricular zone (VZ) and subventricular zone (SVZ) during embryogenesis. RP58 is a transcriptional repressor that is strongly expressed in the developing brain and plays an essential role in corticogenesis. The expression of RP58 is strictly regulated in a time-dependent and spatially restricted manner. It is maximally expressed in E15-16 embryonic cerebral cortex, localized specifically to the… CONTINUE READING