The 5' adenosine monophosphate-activated protein kinase: regulating the ebb and flow of cellular energetics.

@article{Karagounis2009The5A,
  title={The 5' adenosine monophosphate-activated protein kinase: regulating the ebb and flow of cellular energetics.},
  author={Leonidas G Karagounis and John A. Hawley},
  journal={The international journal of biochemistry & cell biology},
  year={2009},
  volume={41 12},
  pages={2360-3}
}
The 5' adenosine monophosphate-activated protein kinase (AMPK) is a heterotrimeric, evolutionary conserved enzyme which has emerged as a critical regulator of skeletal muscle cellular bioenergetics. AMPK is activated by both chemical (adipokines) and mechanical (stretch, contraction) stimuli leading to metabolic changes within muscle cells that include increased fatty acid oxidation, glucose uptake and glycolysis, as well as the stimulation and regulation of mitochondrial biogenesis… CONTINUE READING