The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway.

@article{Mitchell2010The5C,
  title={The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway.},
  author={Sarah F. Mitchell and Sarah E. Walker and Mikkel A Algire and Eunchan Park and Alan G Hinnebusch and Jon R. Lorsch},
  journal={Molecular cell},
  year={2010},
  volume={39 6},
  pages={950-62}
}
Translational control is frequently exerted at the stage of mRNA recruitment to the initiating ribosome. We have reconstituted mRNA recruitment to the 43S preinitiation complex (PIC) using purified S. cerevisiae components. We show that eIF3 and the eIF4 factors not only stabilize binding of mRNA to the PIC, they also dramatically increase the rate of recruitment. Although capped mRNAs require eIF3 and the eIF4 factors for efficient recruitment to the PIC, uncapped mRNAs can be recruited in the… CONTINUE READING

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