The 4q27 locus and prostate cancer risk

  title={The 4q27 locus and prostate cancer risk},
  author={Elizabeth A. Tindall and Hoa N. Hoang and Melissa C. Southey and Dallas English and John L. Hopper and Graham G. Giles and Gianluca Severi and Vanessa M. Hayes},
  booktitle={BMC Cancer},
Chronic inflammation is considered to be implicated in the development of prostate cancer. In this study we are the first to investigate a potential association between variants in an autoimmune related region on chromosome 4q27 and prostate cancer risk. This region harbors two cytokine genes IL-2 and the recently described IL-21. We genotyped six variants previously associated with autoimmune disease (namely rs13151961, rs13119723, rs17388568, rs3136534, rs6822844 and rs6840978) and one… CONTINUE READING

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