The 4G/5G sequence polymorphism in the promoter of plasminogen activator inhibitor-1 (PAI-1) gene: relationship to plasma PAI-1 level in venous thromboembolism.

@article{Stegnar1998The4S,
  title={The 4G/5G sequence polymorphism in the promoter of plasminogen activator inhibitor-1 (PAI-1) gene: relationship to plasma PAI-1 level in venous thromboembolism.},
  author={Mojca Stegnar and P Uhrin and Polona Peternel and Alenka Mavri and B Salobir-Pajnic and Janez Stare and Bernd R. Binder},
  journal={Thrombosis and haemostasis},
  year={1998},
  volume={79 5},
  pages={975-9}
}
Impaired fibrinolysis due to increased plasminogen activator inhibitor-1 (PAI-1) is observed in up to 40% of patients with venous thromboembolism and might be causally related to the disease. There is evidence that genetic variations in the promoter of the PAI-1 gene and metabolic factors contribute to increased plasma PAI-1 levels. A single nucleotide insertion/deletion (4G/5G) polymorphism in the promoter region of the PAI-1 gene and metabolic factors were studied in 158 unrelated patients… CONTINUE READING

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