The 4F9 antigen is a member of the tetra spans transmembrane protein family and functions as an accessory molecule in T cell activation and adhesion.

@article{Nojima1993The4A,
  title={The 4F9 antigen is a member of the tetra spans transmembrane protein family and functions as an accessory molecule in T cell activation and adhesion.},
  author={Yoshihisa Nojima and Tomonori Hirose and Kouichi Tachibana and Tadao Tanaka and Li Ye Shi and J M Doshen and G J Freeman and Stuart F. Schlossman and Chikao Morimoto},
  journal={Cellular immunology},
  year={1993},
  volume={152 1},
  pages={249-60}
}
In this report, we describe a 43- to 50-kDa protein, which may function as a costimulatory molecule for full activation of human T cells. This Ag, defined by a mouse monoclonal antibody (mAb) anti-4F9, is primarily distributed on "helper/inducer" or "memory" CD4+CD45RO+ subset. Like mAbs against many other accessory/costimulatory molecules, coimmobilization of anti-4F9 with anti-CD3 resulted in synergistic T cell proliferation. In addition, immobilized anti-4F9 on plastic plates induced T cell… CONTINUE READING

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