The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation.

@article{Jin2009The4A,
  title={The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation.},
  author={Zhigang Jin and Jianli Shi and Amit Saraf and Wenyan Mei and G Zhu and Stefan Strack and Jing Yang},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 11},
  pages={7190-200}
}
Alternative translation is an underappreciated post-transcriptional regulation mechanism. Although only a small number of genes are found to be alternatively translated, most genes undergoing alternative translation play important roles in tumorigenesis and development. Protein phosphatase 2A (PP2A) is involved in many cellular events during tumorigenesis and development. The specificity, localization, and activity of PP2A are regulated by B regulatory subunits. B56epsilon, a member of the B56… CONTINUE READING