The 434(G>C) polymorphism within the coding sequence of Eosinophil Cationic Protein (ECP) correlates with the natural course of Schistosoma mansoni infection.

@article{Eriksson2007The4P,
  title={The 434(G>C) polymorphism within the coding sequence of Eosinophil Cationic Protein (ECP) correlates with the natural course of Schistosoma mansoni infection.},
  author={Jenny D Eriksson and Claus M. Reimert and Narcis B. Kabatereine and Francis Kazibwe and Edmund K. Ireri and Hilda Kadzo and Hanan B Eltahir and Abdelrahim Osman Mohamed and Birgitte J. Vennervald and Per Venge},
  journal={International journal for parasitology},
  year={2007},
  volume={37 12},
  pages={1359-66}
}
Schistosomiasis is a chronic parasitic infection with over 200 million people infected worldwide. In Schistosoma mansoni infections, parasite-derived eggs get trapped in the liver, causing the formation of granulomas, which may develop into periportal fibrosis and portal hypertension, and thus severe morbidity. Eosinophil cationic protein (ECP) is a secretory protein of eosinophil granulocytes that efficiently kills the larval stage of S. mansoni, but also affects fibroblast functions. We have… CONTINUE READING