The 4-anilinoquinazoline class of inhibitors of the erbB family of receptor tyrosine kinases.


The erbB family of receptor tyrosine kinase enzymes, and particularly EGFR and HER2/neu, have become important targets for potential anticancer drugs. The substrate protein binding site theoretically is the more attractive intracellular target on these enzymes, possessing lower homology than the ATP site between different receptor kinases. However, a major… (More)