The 3A protein from multiple picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIβ.

@article{Greninger2012The3P,
  title={The 3A protein from multiple picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIβ.},
  author={Alexander L Greninger and Giselle M. Knudsen and Miguel Betegon and Alma L. Burlingame and Joseph L. DeRisi},
  journal={Journal of virology},
  year={2012},
  volume={86 7},
  pages={
          3605-16
        }
}
The activity of phosphatidylinositol 4-kinase class III beta (PI4KIIIβ) has been shown to be required for the replication of multiple picornaviruses; however, it is unclear whether a physical association between PI4KIIIβ and the viral replication machinery exists and, if it does, whether association is necessary. We examined the ability of the 3A protein from 18 different picornaviruses to form a complex with PI4KIIIβ by affinity purification of Strep-Tagged transiently transfected constructs… CONTINUE READING
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