The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription.

@article{Kroeger1997TheT,
  title={The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription.},
  author={Karen Marie Kroeger and Kylie S. Carville and Lawrence J. Abraham},
  journal={Molecular immunology},
  year={1997},
  volume={34 5},
  pages={391-9}
}
Since the tumor necrosis factor alpha (TNF-alpha) gene was found to be located in the central major histocompatibility complex (MHC) there has been much speculation concerning a genetic association between particular TNF alleles and disease susceptibility. A relationship between the MHC haplotype A1, B8, DR3, TNF-alpha expression levels and susceptibility to autoimmune disease has been suggested by several groups. The identification of the -308 polymorphism and its association with the HLA A1… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 346 extracted citations

Similar Papers

Loading similar papers…