The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription.

  title={The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription.},
  author={Karen Marie Kroeger and Kylie S. Carville and Lawrence J. Abraham},
  journal={Molecular immunology},
  volume={34 5},
Since the tumor necrosis factor alpha (TNF-alpha) gene was found to be located in the central major histocompatibility complex (MHC) there has been much speculation concerning a genetic association between particular TNF alleles and disease susceptibility. A relationship between the MHC haplotype A1, B8, DR3, TNF-alpha expression levels and susceptibility to autoimmune disease has been suggested by several groups. The identification of the -308 polymorphism and its association with the HLA A1… CONTINUE READING
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