The 3' UTR of the human CTLA4 mRNA can regulate mRNA stability and translational efficiency.


T cell activation results from the integration of signals generated through the T cell antigen receptor-CD3 complex with those from additional positive and negative regulatory pathways mainly mediated by the engagement of costimulatory receptors on T cells. Disruption of this balance leads to a defective immune response or alternative over-activation of the… (More)