The 3′ Untranslated Region of a Plant Viral RNA Directs Efficient Cap-Independent Translation in Plant and Mammalian Systems

@article{Kraft2019The3U,
  title={The 3′ Untranslated Region of a Plant Viral RNA Directs Efficient Cap-Independent Translation in Plant and Mammalian Systems},
  author={Jelena J. Kraft and M. S. Peterson and S. K. Cho and Zhaohui Wang and A. Hui and Aur{\'e}lie M. Rakotondrafara and K. Treder and C. L. Miller and W. Miller},
  journal={Pathogens},
  year={2019},
  volume={8}
}
  • Jelena J. Kraft, M. S. Peterson, +6 authors W. Miller
  • Published 2019
  • Biology, Medicine
  • Pathogens
  • Many plant viral RNA genomes lack a 5′ cap, and instead are translated via a cap-independent translation element (CITE) in the 3′ untranslated region (UTR). The panicum mosaic virus-like CITE (PTE), found in many plant viral RNAs, binds and requires the cap-binding translation initiation factor eIF4E to facilitate translation. eIF4E is structurally conserved between plants and animals, so we tested cap-independent translation efficiency of PTEs of nine plant viruses in plant and mammalian… CONTINUE READING
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