The 3′–5′ exonucleases

@article{Shevelev2002The3E,
  title={The 3′–5′ exonucleases},
  author={Igor V. Shevelev and Ulrich Hübscher},
  journal={Nature Reviews Molecular Cell Biology},
  year={2002},
  volume={3},
  pages={364-376}
}
Over the past few years, several new 3′–5′ exonucleases have been identified. In vitro studies of these enzymes have uncovered much about their potential functions in vivo, and certain organisms with a defect in 3′–5′ exonucleases have an increased susceptibility to cancer, especially under conditions of stress. Here, we look at not only the newly discovered enzymes, but also at the roles of other 3′–5′ exonucleases in the quality control of DNA synthesis, where they act as proofreading… Expand

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TLDR
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[Antimutagenic role of autonomous 3'-->5'-exonucleases].
TLDR
An investigation of thirty objects from all three kingdoms of life has shown that AE increase significantly the intracellular ratio of 3′ → 5′-exonuclease to DNA polymerase activities in a wide phylogenetic variety of species, which always leads to the increasing fidelity of DNA biosynthesis. Expand
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