The 3–7 fragment of angiotensin II is probably responsible for its psychoactive properties

  title={The 3–7 fragment of angiotensin II is probably responsible for its psychoactive properties},
  author={J. Braszko and J. Własienko and W. Koziołkiewicz and A. Janecka and K. Wi{\vs}niewski},
  journal={Brain Research},
  • J. Braszko, J. Własienko, +2 authors K. Wišniewski
  • Published 1991
  • Biology, Medicine
  • Brain Research
  • The abilities of angiotensin II-(3-7)-pentapeptide (A-II-(3-7), 1 nmol) and angiotensin II (A-II, 1 nmol) to influence rat's psychomotor and cognitive behaviours were compared. Both peptides, given intracerebroventricularly (i.c.v.), 15 min before the experiment, increased number of crossings, rearings and bar approaches in the open field. A-II-(3-7) as well as A-II, at the same doses and routes, significantly intensified stereotypy produced by apomorphine (1 mg/kg) and amphetamine (6.5 mg/kg… CONTINUE READING
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