The 3β-hydroxysteroid dehydrogenase inhibitor trilostane shows antidepressant properties in mice

@article{Espallergues2009The3D,
  title={The 3β-hydroxysteroid dehydrogenase inhibitor trilostane shows antidepressant properties in mice},
  author={J. Espallergues and L. Givalois and Jamal Temsamani and C. Laruelle and T. Maurice},
  journal={Psychoneuroendocrinology},
  year={2009},
  volume={34},
  pages={644-659}
}
  • J. Espallergues, L. Givalois, +2 authors T. Maurice
  • Published 2009
  • Medicine
  • Psychoneuroendocrinology
  • Changes in neuro(active)steroid levels are involved in depressive states and mood disorders. For instance, dehydroepiandrosterone or pregnenolone sulfate showed anti-stress and antidepressant activity in rodents and regulation of allopregnanolone levels appeared to be one of the consequence of an effective antidepressant therapy in patients. 4alpha,5-Epoxy-17beta-hydroxy-3-oxo-5alpha-androstane-2alpha-carbonitrile (trilostane) inhibits the activity of 3beta-hydroxysteroid dehydrogenase (3beta… CONTINUE READING
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