The 3'-untranslated regions of cytoskeletal muscle mRNAs inhibit translation by activating the double-stranded RNA-dependent protein kinase PKR.

@article{Nussbaum2002The3R,
  title={The 3'-untranslated regions of cytoskeletal muscle mRNAs inhibit translation by activating the double-stranded RNA-dependent protein kinase PKR.},
  author={Jean M Nussbaum and Shobha Gunnery and Michael B. Mathews},
  journal={Nucleic acids research},
  year={2002},
  volume={30 5},
  pages={1205-12}
}
Cytoskeletal proteins are associated with actin in the microfilaments and have a major role in microfilament assembly and function. The expression of some of these proteins has been implicated in cell growth and transformation. Specifically, the 3'-untranslated regions (3'-UTRs) of tropomyosin, troponin and cardiac actin can induce muscle cell differentiation and appear to function as tumor suppressors. These RNA sequences are predicted to fold to form secondary structures with extended… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Potential role for snoRNAs in PKR activation during metabolic stress.

Proceedings of the National Academy of Sciences of the United States of America • 2015

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.

Proceedings of the National Academy of Sciences of the United States of America • 2013

Similar Papers

Loading similar papers…