The 3' end CCA of mature tRNA is an antideterminant for eukaryotic 3'-tRNase.

@article{Mohan1999The3E,
  title={The 3' end CCA of mature tRNA is an antideterminant for eukaryotic 3'-tRNase.},
  author={Avinash Lalith Mohan and Sheena Whyte and Xueying Wang and Masayuki Nashimoto and Louis Levinger},
  journal={RNA},
  year={1999},
  volume={5 2},
  pages={
          245-56
        }
}
Cytoplasmic tRNAs undergo posttranscriptional 5' and 3' end processing in the eukaryotic nucleus, and CCA (which forms the mature 3' end of all tRNAs) must be added by tRNA nucleotidyl transferase before tRNA can be aminoacylated and utilized in translation. Eukaryotic 3'-tRNase can endonucleolytically remove a 3' end trailer by cleaving on the 3' side of the discriminator base (the unpaired nucleotide 3' of the last base pair of the acceptor stem). This reaction proceeds despite a wide range… CONTINUE READING
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