The 3' conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants.

@article{Paulsen1993The3C,
  title={The 3' conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants.},
  author={Ian T. Paulsen and Tim G. Littlejohn and Peter R{\aa}dstr{\"o}m and Lars Sundstr{\"o}m and Ola Sk{\"o}ld and G{\"o}te Swedberg and Ronald A. Skurray},
  journal={Antimicrobial agents and chemotherapy},
  year={1993},
  volume={37 4},
  pages={761-8}
}
Nucleotide sequence analysis of ORF1 from the integron on the broad-host-range plasmid R751 revealed that the first 94 of 110 codons of ORF1 from R751 are identical to ORF4, an open reading frame from the 3' conserved segment of other integrons found in gram-negative bacteria, after which point they diverged completely. The predicted products of both ORF1 and ORF4 share homology with the multidrug exporter QacC. Phenotypic analysis revealed that ORF1 specifies a resistance profile to… CONTINUE READING

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