The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1.

@article{SluisCremer2005The3G,
  title={The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1.},
  author={Nicolas Sluis-Cremer and Dominique Arion and Urvi M Parikh and Dianna Koontz and Raymond F Schinazi and John W Mellors and Michael A. Parniak},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 32},
  pages={29047-52}
}
The mechanism of human immunodeficiency virus (HIV) 1 resistance to 3'-azido-3'-deoxythymidine (AZT) involves reverse transcriptase (RT)-catalyzed phosphorolytic excision of the chain-terminating AZT-5'-monophosphate (AZTMP). Primers terminated with AZTMP are generally better substrates for this reaction than those terminated with 2',3'-dideoxynucleoside-5'-monophosphate (2',3'-ddNMP) analogs that lack a 3'-azido moiety. This led to the hypothesis that the 3'-azido group is a major structural… CONTINUE READING

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Retroviral reverse transcriptases

Cellular and Molecular Life Sciences • 2010
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Nature Structural &Molecular Biology • 2010

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