The 2B subdomain of Rep helicase links translocation along DNA with protein displacement

@inproceedings{Brning2018The2S,
  title={The 2B subdomain of Rep helicase links translocation along DNA with protein displacement},
  author={Jan-Gert Br{\"u}ning and Jamieson L Howard and Kamila K Myka and Mark Simon Dillingham and Peter McGlynn},
  booktitle={Nucleic acids research},
  year={2018}
}
Helicases catalyse DNA and RNA strand separation. Proteins bound to the nucleic acid must also be displaced in order to unwind DNA. This is exemplified by accessory helicases that clear protein barriers from DNA ahead of advancing replication forks. How helicases catalyse DNA unwinding is increasingly well understood but how protein displacement is achieved is unclear. Escherichia coli Rep accessory replicative helicase lacking one of its four subdomains, 2B, has been shown to be hyperactivated… CONTINUE READING
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