The 26S proteasome: a molecular machine designed for controlled proteolysis.

@article{Voges1999The2P,
  title={The 26S proteasome: a molecular machine designed for controlled proteolysis.},
  author={D. Voges and P. Zwickl and W. Baumeister},
  journal={Annual review of biochemistry},
  year={1999},
  volume={68},
  pages={
          1015-68
        }
}
In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteasome pathway. The 26S proteasome is a 2.5-MDa molecular machine built from approximately 31 different subunits, which catalyzes protein degradation. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins. The regulatory complexes are also implicated in unfolding and translocation of… Expand
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26 S proteasomes function as stable entities.
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