The 24-hour lithium level as a prognosticator of dosage requirements: a 2-year follow-up study.

  title={The 24-hour lithium level as a prognosticator of dosage requirements: a 2-year follow-up study.},
  author={Cooper Tb and Simpson Gm},
  journal={American Journal of Psychiatry},
: The authors have previously described a technique whereby individual lithium dosage requirements can be predicted from 24-hour blood samples. Further experience over a 2-year period has shown the predictions to be reproducible over time. A micromethod for lithium determination is described, as are several cases in which aberrant results were found to indicate inadequate laboratory techniques or patients' failure to take medication. Because the technique reveals immediately those patients at… 
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In a pilot study it is shown that the plasma lithium concentration can be raised from 0 to 2 mmol/l in a few hours, inducing changes in both kidney function and neuropsychological tests after only short delay, suggesting that mania might be quickly controlled with rapid dosage and opens up a new way of analysing the mechanisms of lithium action.
Lithium dosage guide for prepubertal children: a preliminary report.
Some practical aspects of lithium treatment: blood levels, dosage prediction, and slow-release preparations.
  • P. Grof
  • Medicine, Psychology
    Archives of general psychiatry
  • 1979
The purpose of this report is to discuss practical issues in lithium management, focusing on ( a ) the reasons for standardizing procedures for drawing blood for the determination of serum lithium
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A technique is described that enables a physician to determine individual patient dosage requirements for nortriptyline from a single 24-hour blood sample and reveals immediately those patients at the extremes of dosage ranges, toxicity and the need for time-consuming titration of the dosage regimen can be avoided.
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  • A. Amdisen
  • Medicine, Psychology
    Clinical pharmacokinetics
  • 1977
Results of 25 years’ clinical experience and more recent knowledge of the clinical pharmacokinetics of the lithium ion have shown that a serum level standardised with regard to dosage schedule, a fixed interval between last intake and blood sampling, blood sampling at the same hour, and choice of tablet brand, must all be considered essential to adjust dosage and to correctly monitor treatment.
Bayesian Forecasting of Serum Lithium Concentrations
Twelve pharmacokinetic methods of estimating lithium maintenance dosage requirements were compared in 21 patients with bipolar illness, finding no statistically significant differences in bias or precision between any of the methods.
A Review of Lithium Dosing Methods
A well‐designed Bayesian approach to the dosing of lithium, although not currently available, would be the most useful.
APriori lithium dosage regimen using population characteristics of pharmacokinetic parameters
Universal dosages are shown to be unsatisfactory, however, certain dosage regimens individualized with respect to the renal clearance value of lithium and based on two or three daily intakes can give excellent results even when conventional dosage forms are used.