The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

  title={The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans},
  author={B. J. Reinhart and F. Slack and M. Basson and A. E. Pasquinelli and J. C. Bettinger and A. Rougvie and H. Horvitz and G. Ruvkun},
  • B. J. Reinhart, F. Slack, +5 authors G. Ruvkun
  • Published 2000
  • Medicine, Biology
  • Nature
  • The C. elegans heterochronic gene pathway consists of a cascade of regulatory genes that are temporally controlled to specify the timing of developmental events. Mutations in heterochronic genes cause temporal transformations in cell fates in which stage-specific events are omitted or reiterated. Here we show that let-7 is a heterochronic switch gene. Loss of let-7 gene activity causes reiteration of larval cell fates during the adult stage, whereas increased let-7 gene dosage causes precocious… CONTINUE READING

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