The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection

@article{Dieud2015The2P,
  title={The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection},
  author={M{\'e}lanie Dieud{\'e} and Christina Bell and Julie Turgeon and Deborah Beillevaire and Luc Pomerleau and Bing Yang and Katia Hamelin and Shijie Qi and Nicolas Pietrancosta and Chanel B{\'e}land and Wahiba Dhahri and J F Cailhier and Matthieu Rousseau and Anne-Claire Duchez and Tania L{\'e}vesque and Arthur Lau and Christiane Rondeau and D. F. Gingras and Danie Muruve and Alain Rivard and H{\'e}lo{\"i}se Cardinal and Claude Perreault and Michel Desjardins and Eric Boilard and Pierre Thibault and M. Hebert},
  journal={Science Translational Medicine},
  year={2015},
  volume={7},
  pages={318ra200-318ra200}
}
Autoantibodies to components of apoptotic cells, such as anti-perlecan antibodies, contribute to rejection in organ transplant recipients. However, mechanisms of immunization to apoptotic components remain largely uncharacterized. We used large-scale proteomics, with validation by electron microscopy and biochemical methods, to compare the protein profiles of apoptotic bodies and apoptotic exosome-like vesicles, smaller extracellular vesicles released by endothelial cells downstream of caspase… CONTINUE READING